Professor Paul Bishop PhD, FRCOphth

Photograph of Paul Bishop

Professor of Ophthalmology and Matrix Biology

Role

Lead, Centre for Hearing and Vision Research, Institute of Human Development

Consultant Ophthalmologist, Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust

Co-Director of the Centre for Advanced Discovery and Experimental Therapeutics (CADET), Manchester Biomedical Research Centre

Chair of Medical Advisory Board, RP Fighting Blindness

Chair of Research Comittee, Macular Society

Research

 Research Interests:

  • Age-related macular degeneration
  • Complications of diabetes (especially retinopathy)
  • Hereditary retinal degenerations
  • Extracellular matrix and its role in ocular disease
  • Regulation of angiogenesis

 Links:

Manchester NIHR Biomedical Research Centre (www.manchesterbrc.org)

CADET (www.manchesterbrc.org/OurFacilities/CADET.php)

Biography

Paul is an ophthalmologist and clinician scientist.  Soon after graduating in Medicine at Nottingham University he moved to Manchester.  This is where he undertook his postgraduate medical training and he was appointed as a Consultant Ophthalmologist at Manchester Royal Eye Hospital in 1998.  He specialises in the management of medical retinal conditions.

Whilst training as an ophthalmologist he completed a PhD in biochemistry (1993).  From 1991-2006 he held successive Wellcome Trust Clinical Fellowships including a Vision Research Training Fellowship, a Clinician Scientist Fellowship and a Senior Clinical Fellowship; he was appointed to a personal Chair in 2006.  

He is currently Co-Director of CADET.  This Centre aims to discover and develop new medicines for common age-related diseases.  It primarily uses proteomics and metabolomics as discovery platforms, and is taking new drugs through to clinical trials.

The focus of  his ophthalmic research is medical retinal disease and he has research projects spanning from laboratory-based research into new treatments for age-related macular degeneration and diabetic retinopathy through to leading major interventional clinical trials.

Qualifications

B Med Sci Hons (University of Nottingham)

BM BS  (University of Nottingham)

FRCS (London); FRCOphth

PhD (Biochemistry, University of Manchester)

CCT in Ophthalmology (Specialist Training Authority of the UK)

Publications

2013

  • Balaskas, K., Hovan, M., Mahmood, S. & Bishop, P (2013). Ranibizumab for the management of Sorsby fundus dystrophy. Eye (Lond), 27(1), 101-2. eScholarID:185042 | PMID:23099917 | DOI:10.1038/eye.2012.221
  • Clark, S., Ridge, L., Herbert, A., Hakobyan, S., Mulloy, B., Lennon, R., Würzner, R., Morgan, B., Uhrín, D., Bishop, P. & Day, A (2013). Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol, 190(5), 2049-57. eScholarID:195266 | PMID:23365078 | DOI:10.4049/jimmunol.1201751
  • Fritsche, et al. (2013). Seven new loci associated with age-related macular degeneration. Nat Genet, 45(4), 433-9, 439e1-2. eScholarID:195267 | PMID:23455636 | DOI:10.1038/ng.2578

2012

  • Cipriani V, Leung HT, Plagnol V, Bunce C, Khan JC, Shahid H, Moore AT, Harding SP, Bishop PN, Hayward C, Campbell S, Armbrecht AM, Dhillon B, Deary IJ, Campbell H, Dunlop M, Dominiczak AF, Mann SS, Jenkins SA, Webster AR, Bird AC, Lathrop M, Zelenika D, Souied EH, Sahel JA, Leveilland T; French AMD Investigators, Cree AJ, Gibson J, Ennis S, Lotery AJ, Wright AF, Clayton DG, Yates JR. (2012). Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. Hum Mol Genet, eScholarID:165035
  • Cipriani V, Matharu BK, Khan JC, Shahid H, Hayward C, Wright AF, Armbrecht M, Dhillon B, Harding SP, Bishop PN, Bunce C, Clayton DG, Moore AT, Yates JRW. (2012). No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration. Eur J Hum Genet, 20, 1-2. eScholarID:133471 | DOI:10.1038/ejhg.2011.118
  • Goff, M., Lu, H., Ugarte, M., Henry, S., Takanosu, M., Mayne, R. & Bishop, P (2012). The vitreous glycoprotein opticin inhibits preretinal neovascularization. Invest Ophthalmol Vis Sci, 53(1), 228-34. eScholarID:177850 | PMID:22159013 | DOI:10.1167/iovs.11-8514
  • Investigators, I.S., Chakravarthy, U., Harding, S., Rogers, C., Downes, S., Lotery, A., Wordsworth, S. & Reeves, B (2012). Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology, 119(7), 1399-411. eScholarID:177852 | PMID:22578446 | DOI:10.1016/j.ophtha.2012.04.015
  • Keenan, T., Clark, S., Unwin, R., Ridge, L., Day, A. & Bishop, P (2012). Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera. Invest Ophthalmol Vis Sci, 53(12), 7528-38. eScholarID:185044 | PMID:23074202 | DOI:10.1167/iovs.12-10797
  • Le Goff, M., Sutton, M., Slevin, M., Latif, A., Humphries, M. & Bishop, P (2012). Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. J Biol Chem, 287(33), 28027-36. eScholarID:177851 | PMID:22669977 | DOI:10.1074/jbc.M111.331157
  • Shahid H, Khan JC, Cipriani V, Sepp T, Matharu BK, Bunce C, Harding SP, Clayton DG, Moore AT, Yates JR; Genetic Factors in AMD Study Group. (2012). Age-related macular degeneration: the importance of family history as a risk factor. Br J Opthalmol, 96(3), 427-31. eScholarID:165015 | DOI:10.1136/bjophthalmol-2011-300193
  • Ugarte, M., Brown, M., Hollywood, K., Cooper, G., Bishop, P. & Dunn, W (2012). Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med, 4(4), 35. eScholarID:177849 | PMID:22546713 | DOI:10.1186/gm334
  • Ugarte, M., Grime, G., Lord, G., Geraki, K., Collingwood, J., Finnegan, M., Farnfield, H., Merchant, M., Bailey, M., Ward, N., Foster, P., Bishop, P. & Osborne, N (2012). Concentration of various trace elements in the rat retina and their distribution in different structures. Metallomics, 4(12), 1245-54. eScholarID:185043 | PMID:23093062 | DOI:10.1039/c2mt20157g

2011

  • Cehajic-Kapetanovic J, Le Goff MM, Allen A, Lucas RJ, Bishop PN. (2011). Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2. Mol. Vision, 17, 1171-1183. eScholarID:133469
  • Clark SJ, Keenan TDL, Fielder HL, Collinson LJ, Holley RJ, Merry CLR, van Kuppevelt TH, Day AJ, Bishop PN. (2011). Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid and sclera. Invest. Ophthalmol. Vis. Sci, 52, 6511-6521. eScholarID:133472 | DOI:10.1167/iovs.11-7909
  • Le Goff MM, Lu H, Ugarte M, Henry S, Takanosu M, Mayne R, Bishop PN. (2011). The vitreous glycoprotein opticin inhibits preretinal neovascularization. Invest. Ophthalmol. Vis. Sci, In Press, eScholarID:143845 | DOI:10.1167/iovs.11-8514
  • (2011) Opticin nucleic acid administration reduces blood vessel formation. eScholarID:165040

2010

  • Bishop PN. (2010). Molecular composition of the vitreous and aging changes. In Editor in Chief: D. Dartt. Section Editor P. Bishop (Ed.), Encyclopaedia of the eye. Elsevier and ScienceDirect. eScholarID:109731
  • Cehajic-Kapetanovic, J., Bishop, P., Liyanage, S., King, T., Muldoon, M. & Wearne, I (2010). A novel Ocular Anaesthetic Scoring System, OASS, tool to measure both motor and sensory function following local anaesthesia. Br J Ophthalmol, 94(1), 28-32. eScholarID:109690 | DOI:bjo.2008.155572 [pii] 10.1136/bjo.2008.155572
  • Clark, S., Bishop, P. & Day, A (2010). Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology. Biochem Soc Trans, 38(5), 1342-8. eScholarID:109689 | DOI:BST0381342 [pii] 10.1042/BST0381342
  • Clark, S., Perveen, R., Hakobyan, S., Morgan, B., Sim, R., Bishop, P. & Day, A (2010). Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. J Biol Chem, 285(39), 30192-202. eScholarID:109688 | DOI:10.1074/jbc.M110.103986
  • Jones, R., Ridley, C., Jowitt, T., Wang, M., Howard, M., Bobola, N., Wang, T., Bishop, P., Kielty, C., Baldock, C., Lotery, A. & Trump, D (2010). Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa. Invest Ophthalmol Vis Sci, 51(5), 2356-62. eScholarID:109692 | DOI:iovs.09-4620 [pii] 10.1167/iovs.09-4620
  • Nishimura, D., Baye, L., Perveen, R., Searby, C., Avila-Fernandez, A., Pereiro, I., Ayuso, C., Valverde, D., Bishop, P., Manson, F., Urquhart, J., Stone, E., Slusarski, D., Black, G. & Sheffield, V (2010). Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71. American Journal of Human Genetics, 86(5), 686-95. eScholarID:109691 | DOI:10.1016/j.ajhg.2010.03.005
  • Pattwell, D., Sheridan, C., Le Goff, M., Bishop, P. & Hiscott, P (2010). Localisation of opticin in human proliferative retinal disease. Exp Eye Res, 90(3), 461-4. eScholarID:109693 | DOI:S0014-4835(09)00354-6 [pii] 10.1016/j.exer.2009.12.007
  • Anthony J. Day, Simon J. Clark, Paul N. Bishop, Robert B. Simm, Anna M. Blom, Dick Heinegard. (2010) Screening assays for binding antagonists of the AMD-associated variant of factor H (H384). eScholarID:109694

2009

  • Bishop PN. (2009). Vitreous as a Substrate for Vitreolysis. Dev Ophthalmol, 44, 7-19. eScholarID:1d20875 | DOI:10.1159/000223939
  • Jones, R, Wang, M, Jowitt, T, Ridley, C, Mellody, K, Howard, M, Wang, T, Bishop, PN, Lotery, A, Kielty, C, Baldock, C, Trump, D. (2009). Fibulin 5 forms a compact dimer in physiological solutions. J Biol Chem, eScholarID:1d20248 | DOI:10.1074/jbc.M109.011627
  • Kalyanasundaram T, Black GCM, O'Sullivan J, Bishop PN. (2009). A novel peripherin/RDS mutation resulting in a retinal dystrophy with phenotypic variation. Eye, 23( 1), 237-239. eScholarID:1d20124 | DOI:10.1038/eye.2008.33

2008

  • Bishop PN. (2008). Disorders of the vitreous. Pathobiology of Ocular Disease: A Dynamic Approach. New York: Marcel Dekker. eScholarID:84471
  • Le Goff M, Bishop PN. (2008). Adult vitreous structure and postnatal changes. Eye, 22( 10), 1214-1222. eScholarID:1d20879 | DOI:10.1038/eye.2008.21
  • McAlinden A, Majava M, Bishop PN, Perveen R, Black GC, Pierpont ME, Ala-Kokko L, Männikkö M. (2008). Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome. Human mutation, 29(1), 83-90. eScholarID:1c7206 | PMID:17721977 | DOI:10.1002/humu.20603
  • Monfort J, Tardif G, Roughley P, Reboul P, Boileau C, Bishop PN, Pelletier JP, Martel-Pelletier J. (2008). Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. Osteoarthritis Cartilage, 16, 749-755. eScholarID:1d16972 | DOI:10.1016/j.joca.2007.11.007
  • Park H, Huxley-Jones J, Boot-Handford RP, Bishop PN, Attwood TK, Bella J. (2008). LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage. BMC genomics, 9, eScholarID:1c8192 | PMID:19077264 | DOI:10.1186/1471-2164-9-599
  • Paul N. Bishop. (2008) Class III SLRP agonists for the reduction of blood vessel formation. eScholarID:84465

2007

  • Assheton DC, Guerin EP, Sheridan CM, Bishop PN, Hiscott PS. (2007). Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. The British journal of ophthalmology, 91(2), 230-232. eScholarID:1c7208 | PMID:17005546 | DOI:10.1136/bjo.2006.102582
  • Le Goff MM, Bishop PN. (2007). Focus on molecules: opticin. Experimental eye research, 85(3), 303-304. eScholarID:1c7209 | PMID:16678159 | DOI:10.1016/j.exer.2006.03.012
  • Majava M, Bishop PN, Hägg P, Scott PG, Rice A, Inglehearn C, Hammond CJ, Spector TD, Ala-Kokko L, Männikkö M. (2007). Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia. Human mutation, 28(4), 336-344. eScholarID:1c7207 | PMID:17117407 | DOI:10.1002/humu.20444

2006

  • Devadason DS, Mahmood S, Stanga PE, Bishop PN. (2006). Solar retinopathy in a patient with bipolar affective disorder. British Journal of Ophthalmology, 90, 247-247. eScholarID:1c5140 | DOI:10.1136/bjo.2005.078550
  • Halfter W, Winzen U, Bishop PN, Eller A. (2006). Regulation of eye size by the retinal basement membrane and vitreous body. Invest Ophthalmol Vis Sci, 47( 8), 3586-3594. eScholarID:1d13921
  • McEwan PA, Scott PG, Bishop PN, Bella J. (2006). Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans. Journal of Structural Biology, 155(2), eScholarID:1c5672 | PMID:16884925 | DOI:10.1016/j.jsb.2006.01.016
  • Scott PG, Bishop PN, Bella J. (2006). On the calculation of the binding force between decorin and collagen. Journal of Biomechanics, 39(6), 1159-1160. eScholarID:1c5674 | DOI:10.1016/j.jbiomech.2006.01.011
  • Scott PG, Dodd CM, Bergmann EM, Sheehan JK, Bishop PN. (2006). Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans. Journal of Biological Chemistry, 281(19), 13324-13332. eScholarID:1c5139 | DOI:10.1074/jbc.M513470200

2005

  • Hindson VJ, Gallagher JT, Halfter W, Bishop PN. (2005). Opticin binds to heparan and chondroitin sulfate proteoglycans. Investigative ophthalmology and visual science, 46(12), 4417-4423. eScholarID:1c4897 | PMID:16303928 | DOI:10.1167/iovs.05-0883
  • Limb GA, Matter K, Murphy G, Cambrey AD, Bishop PN, Morris GE, Khaw PT. (2005). Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis. American journal of pathology, 166(5), 1555-1563. eScholarID:1c4896 | PMID:15855654 | DOI:10.1016/S0002-9440(10)62371-1
  • O"Connor E, Eisenhaber B, Dalley J, Wang T, Missen C, Bulleid N, Bishop PN, Trump D. (2005). Species specific membrane anchoring of nyctalopin, a small leucine-rich repeat protein. Human molecular genetics, 14(13), 1877-1887. eScholarID:1c4462 | PMID:15905181 | DOI:10.1093/hmg/ddi194

2004

  • Bishop PN, Holmes DF, Kadler KE, McLeod D, Bos KJ. (2004). Age-related changes on the surface of vitreous collagen fibrils. Investigative ophthalmology and visual science, 45(4), 1041-1046. eScholarID:1c2193 | PMID:15037566 | DOI:10.1167/iovs.03-1017
  • Ramesh S, Bonshek RE, Bishop PN. (2004). Immunolocalisation of opticin in the human eye. Br. J. Ophthalmol, 88, 697-702. eScholarID:1c2753 | DOI:10.1136/bjo.2003.031989
  • Scott PG, McEwan P, Dodd P, Bergmann E, Bishop PN, Bella J. (2004). Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan. Proceedings of the National Academy of Sciences U. S. A, 101(44), 15633-15638. eScholarID:1c2754 | DOI:10.1073/pnas.0402976101

2003

  • Bishop PN. (2003). Development of vitreous and composition of the vitreous gel. Pathologie du vitre. Ed. G. Brasseur.. eScholarID:165032
  • Le Goff MM, Hindson VJ, Jowitt TA, Scott PG, Bishop PN. (2003). Characterisation of opticin and evidence of stable dimerisation in solution. Journal of Biological Chemistry, 278, eScholarID:1c1401 | PMID:12951322 | DOI:10.1074/jbc.M303117200
  • Scott P G, Dodd C M, Grossman J G, Sheehan J K, Bishop PN. (2003). Light and x-ray scattering show decorin to be a dimer in solution. J Biol Chem, 278, eScholarID:1d7191
  • Wang J, McLeod D, Henson DB, Bishop PN. (2003). Age-dependent changes in the basal retinovitreous adhesion. Investigative ophthalmology and visual science, 44(5), eScholarID:1c1402 | PMID:12714607 | DOI:10.1167/iovs.02-0802

2002

  • Bishop PN, Takanosu M, Le Goff M, Mayne R. (2002). The role of the posterior ciliary body in the biosynthesis of vitreous humour. Eye, 16, eScholarID:1d23786
  • Wang J, McLeod D-, Bishop PN. (2002). Reappraisal of age-dependent changes in the basal retinovitreal adhesion. Investigative Ophthalmology and Vision Sciences, eScholarID:1d24073
  • McLeod D-, Black GCM, Bishop PN. (2002). Vitreous phenotype: genotype correlation in Stickler syndrome. Graefe's Archive of Clinical and Experimental Ophthalmology, 240, eScholarID:17d230

2001

  • Mayne R, Bishop PN, Morris RE, McLeod D. (2001). Fundamentals and Principles of Ophthalmology. American Academy and Ophthalmology Basic and Clinical Science Course, Section 2. (pp. 348-354). American Association of Ophthalmologists 2001.. eScholarID:165033
  • Anderton L, Bishop PN. (2001). Acute visual loss after thioridazine overdose. Am J Psychiatry, 158( 5), eScholarID:1d30423
  • Anderton L, Bishop PN. (2001). Acute visual loss following thioridazine overdose. American Journal Of Psychiatry, 158, eScholarID:1d23889
  • Bos KJ, Holmes DF, Kadler KE, McLeod D, Morris NP, Bishop PN. (2001). Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage. Journal of molecular biology, 306(5), eScholarID:1c1404 | PMID:11237615 | DOI:10.1006/jmbi.2000.4429
  • Bos KJ, Holmes DF, Kadler KE, McLeod D-, Morris NP, Bishop PN. (2001). Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage. Journal of Molecular Biology, 306, eScholarID:1d23734
  • Bos KJ, Holmes DF, Meadows RS, Kadler KE, McLeod D, Bishop PN. (2001). Collagen fibril organisation in mammalian vitreous by freeze etch/rotary shadowing electron microscopy. Micron (Oxford, England : 1993), 32(3), eScholarID:1c1405 | PMID:0011006509
  • Bos KJ, Holmes DF, Meadows RS, Kadler KE, McLeod D-, Bishop PN. (2001). Collagen fibril organization in mammalian vitreous by freeze etching/rotary shadowing electon microscopy. Micron, 32, eScholarID:1d23836
  • Takanosu M, Boyd T, Le Goff M, Henry S, Zhang Y, Bishop PN, Mayne R. (2001). Structure and location of the mouse opticin gene and ocular expression of opticin, PRELP and vitreous humor collagen genes. Invest. Ophthalmol. Vis. Sci, 42, eScholarID:1d2909
  • Takanosu M, Boyd T, Le Goff M, Henry S, Zhang Y, Bishop PN, Mayne R. (2001). Structure and location of the mouse opticin gene and ocular expression of opticin, PRELP and vitreous humor collagen genes. Investigative ophthalmology and visual science, 42, eScholarID:1c2755

2000

  • Bishop PN. (2000). Matrix metalloproteinases and their natural inhibitors. British Journal Of Ophthalmology, 84, eScholarID:1d23838
  • Bishop PN. (2000). Structural macromolecules and supramolecular organisation of the vitreous gel. Progress in retinal and eye research, 19(3), eScholarID:1c1407 | PMID:0010749380 | DOI:10.1016/S1350-9462(99)00016-6
  • Reardon A, Sandell L, Jones CJ, McLeod D, Bishop PN. (2000). Localization of pN-type IIA procollagen on adult bovine vitreous collagen fibrils. Matrix biology : journal of the International Society for Matrix Biology, 19(2), eScholarID:1c1406 | PMID:0010842100
  • Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN. (2000). Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. Journal of Biological Chemistry, 275(3), eScholarID:1c1408 | PMID:0010636917 | DOI:10.1074/jbc.275.3.2123

1999

  • Beatty S, Au Eong KG, McLeod D-, Bishop PN. (1999). Photocoagulation of subfoveal choroidal neovascular membranes in age-related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland. British Journal Of Ophthalmology, 83, 1103-1104. eScholarID:1d23926
  • Beatty S, Rhatigan M, Black GCM, Bishop PN. (1999). Bilateral subfoveal choroidal neovascularization in Turner syndrome: coincidence or consequence? Canadian Journal of Ophthalmology, 34, eScholarID:1d23927
  • Bishop PN, McLeod D-, Reardon A. (1999). The effects of hyaluronan lyase, hyaluronidase and chondroitin ABC lyase on mammalian vitreous gel. Invest. Ophthalmol. Vis. Sci, 40, 2173-2178. eScholarID:1d2920
  • Bishop PN, McLeod D-, Reardon A. (1999). The effects of hyaluronan lyase, hyaluronidase and chondroiton ABC lyase on mammalian vitreous gel. Investigative Ophthalmology and Vision Sciences, 40, eScholarID:1d23929
  • Black GCM, Boulton M, Bishop PN, McLeod D-. (1999). Ophthalmology in the post-genomic era (perspective). British Journal Of Ophthalmology, 83, eScholarID:1d23931
  • S Beatty, KG Au Eong, McLeod D-, Bishop PN. (1999). Photocoagulation of subfoveal choroidal neovascular membrane in age-related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and the Republic of Ireland (commentary). British Journal Of Ophthalmology, 83, 1103-1104. eScholarID:1d24361

1998

  • A Reardon, D Heinegard, McLeod D-, JK Sheehan, Bishop PN. (1998). The large chondroitin sulphate proteoglycan versican in mammalian vitreous. Matrix Biology, 17, 325-333. eScholarID:1d24359
  • Bishop PN, Tullo AB. (1998). Pyoderma gangrenosum and peripheral ulcerative keratitis. Cornea, 17, 346-7. eScholarID:1d24364

1996

  • Bishop PN, S Ayad, S Rearden, McLeod D-, J Sheehan, Kielty CM. (1996). Type VI collagen is present in human and bovine vitreous. Graefe's Archive of Clinical and Experimental Ophthalmology, 234, 710-713. eScholarID:1d24341
  • Bishop PN. (1996). The biochemical structure of mammalian vitreous. Eye, 10, 664-670. eScholarID:1d24365
  • DJ Brown, Bishop PN, H Hamdi, MC Kenney. (1996). Fragmentation of structural components of mammalian vitreous by an endogenous matrix metalloproteinase. Current Eye Research, 15, 439-445. eScholarID:1d24366

1994

  • Bishop PN, Crossman M, McLeod D, Ayad S. (1994). Extraction and characterization of the tissue forms of collagen types II and IX from bovine vitreous. Biochem J, 299 ( Pt 2), 497-505. eScholarID:1d30837
  • Bishop PN, Reardon A, McLeod D, Ayad S. (1994). Identification of alternatively spliced variants of type II procollagen in vitreous. Biochem Biophys Res Commun, 203( 1), eScholarID:1d31514

1993

  • Bishop PN, Boulton M, McLeod D, Stoddart R. (1993). Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments. Glycobiology, 3( 4), 403-12. eScholarID:1d30396

1992

  • Bishop PN, McLeod D, Ayad S. (1992). Extraction and characterisation of the intact form of bovine vitreous type IX collagen. Biochem Biophys Res Commun, 185( 1), 392-7. eScholarID:1d30838

1991

  • Bishop PN, Bonshek RR, Jones C, Ridgway A, Stoddart R. (1991). Lectin binding sites in normal, scarred, and lattice dystrophy corneas. Br J Ophthalmol, 75( 1), 22-7. eScholarID:1d30011
  • Bishop PN, McLeod D, Ayad S. (1991). Extraction of the intact form of type IX collagen from mammalian vitreous. Biochem Soc Trans, 19( 4), eScholarID:1d30305
  • Bishop PN, Tullo A, Killough R, Richmond S. (1991). An immune dot-blot test for the diagnosis of ocular infection with Chlamydia trachomatis. Eye, 5 ( Pt 3), 305-8. eScholarID:1d30003