Professor Adrian Woolf MA MD

Photograph of Adrian Woolf

Chair in Paediatric Science

Room D2515
Michael Smith Building
University of Manchester
Oxford Road
Manchester
M13 9PT
UK

 

Role

University of Manchester

Chair of Paediatric Science, Faculty of Medical and Human Sciences (from 2010)

Centre Lead for Paediatrics and Child Health, Institute of Human Development (from 2014)

Member of Cross Faculty Renal Biology Group

Royal Manchester Children's Hospital

Honorary Consultant in Paediatric Nephrology (from 2010; revalidated 2015)

Member of Greater Manchester Academic Nephrology Network http://www.gmann.co.uk

President Elect, Manchester Paediatric Club section of Manchester Medical Society (from 2015)

Manchester Medical School

Lead for Phase II Nutrition, Metabolism and Excretion Module, Manchester Medical School (2011-2014)

Outside Manchester

Honorary Professor University College London (from 2010)

Kidney Research UK Trustee (from 2012), Alumni Ambassador (from 2013) and Chair of Research Strategy Committee (from 2014),

Member of UK National Renal Research Strategy Steering Group (from 2014)

Member of European Society for Paediatric Nephrology Working Group on Congenital Urinary Tract and Kidney Malformations (from 2014)

Memberships of Committees and Professional Bodies

  • Academic Paediatrics Association GBI
  • American Society of Nephrology
  • Association of Physicians of Great Britain and Ireland
  • British Association for Paediatric Nephrology
  • European Society for Pediatric Nephrology
  • Manchester Medical Society
  • Manchester Paediatric Club
  • Royal College of Paediatrics and Child Health
  • The Renal Association

Research

Current projects

"UK Regenerative Medicine Platform Safety Hub" With S Williams, S Kimber, R Lennon, MC Asselin, P Ranzjad, I Linnik and I Bantounas. Funded by MRC/BBSRC/EPSRC.

"Exploring whether small bowel can be lengthened in an ex vivo model" With A Morabito and R Coletta. Funded by the CMFT Short Bowel Reseach Fund.

"Using zebrafish to implicate novel genes in the early stages of diabetic kidney disease" With DA Long (UCL), S Wilson (UCL) and M Kolatsi-Joannou (UCL). Funded by Diabetes UK.

"Molecular bases of congenital bladder diseases". With NJ Gardiner, WG Newman, NA Roberts and EN HIlton. Funded by MRC.

"RENAL TRACT: novel neurological perspectives on congenital bladder disease". With NJ Gardiner and F Lopes. Funded by Horizon 2020 Marie Sklodowska-Curie Initial Training Network.

"Modelling therapies for surgical adhesions". With SE Herrick , S Namvar, B Wilm (Liverpool) and T Wilm (Liverpool). Funded by MRC.

"Towards novel therapies for a genetic congenital neuropathy affecting the urinary bladder". With EN Hilton, WG Newman and SJ Kimber. Funded by Newlife Foundation.

"Molecular characterisation of bladder exstrophy and related disorders of the lower urinary tract" With WG Newman, G Beaman and M Cervellione. Funded by Newlife Foundation

"Predicting novel genes that contribute to human renal tract malformations using a computational machine learning methodology" With K Hentges, A Doig, HM Stuart and M Kabir. Funded by Kids Kidney Research

Methodological Knowledge

Anatomy and biology of normal and abnormal renal tract development, differentiation and regeneration.

Genetic and biological studies of autonomic and other peripheral neuropathies.

Novel translational therapies using growth factors and precursor cells.

Models of human disease in mice and frogs.

Teaching

University of Manchester MB ChB programme

Lead for Phase II Nutrition, Metabolism and Excretion Module (2011-2014)

Congratulations to NA Roberts for his 2016 Kidney Research UK Training Fellowsip Biological mechanisms of genetic bladder disease

Congratulations on recently awarded theses

2015 PhD HM Stuart (co-supervisor WG Newman) Urofacial syndrome: a genetic model to understand human urinary tract abnormalities

2015 PhD A Gofrehi (second supervisor K Hentges) Microphthalmia genes in mammalian organogenesis

2015 PhD M Randles (primary supervisor R Lennon) Proteomic analyses of kidney glomerular extracelular matrix in health and disease

2015 MRes with Distinction R Taylor (co-supervisor EN Hilton) The heparanase axis and peripheral neuron regeneration

2015 MRes with Distinction R Hall (primary supervisor WG Newman) Genetic characterisation of urofacial syndrome and related conditions of the bladder

Currently supervised PhD students

R Coletta (second supervisor A Morabito)  Exploring whether small bowel can be lengthened in an ex vivo model

E Hindi (primary supervisor NJ Gardiner) Pathogenesis of diabetic urinary bladder disease

F Lopes (second supervisor NJ Gardiner) Novel neurological perspectives on congenital renal tract diseases

T Faris (primary supervisor SJ Kimber) Genetic manipulation of pluripotent stem cells to model kidney disease

Currently supervised MRes students

K Chopra (co-supervisor EN Hilton) Urofacial syndrome and regenerative medicine

S Mezher (co-supervisor P Ranjzad) Mechanisms of fibrosis in chronic kidney disease

Social Responsibility

Trustee, Alumni Lead, and Research Strategy Committee Chair, Kidney Research UK

Undertaking interactive research seminars at primary and secondary schools

 

Biography

In 2010 I took up a new Chair, Professor of Paediatric Science in the Faculty of Medical and Human Sciences at the University of Manchester. I am also an Honorary Consultant in Paediatric Nephrology in the Royal Manchester Children's Hospital.

Previously, in 1998, I established an academic centre for Nephrology and Urology at the UCL Institute of Child Health, London, which I headed until the end of 2009.

A main research aim is to find out why people are sometimes born with abnormal kidneys, ureters and bladders. These are the main causes of children needing long term renal dialysis and kidney transplantation. I am also working on translational therapies, including those based on growth factors and precursor cells, for kidney, bladder and, more recently, neural disease.

My research and development work unites speciality clinical services with new perspectives from Developmental, Cell Biology and Genomic sciences. I have published 138 original research publications. I have supervised clinical and science students leading to 15 PhD, three MD, one MRes, two MSc and one MPhil awarded theses. I currenlty supervise four PhD students (two as lead supervisor) and two MRes students.

In 2015, The Renal Association gave me their Lockwood Award, and I will be their 2016 de Wardener Lecturer, both in recognition of my outstanding record in research and teaching.

From 2006-2009 I undertook a clinic at Great Ormond Street Hospital, London, focusing on renal tract malformations, which had an impact on diagnosis of these conditions and genetic counseling. With clinical genetics and adult nephrology colleagues, I established a similar clinic in the Royal Manchester Children's Hospital in 2010. In 2012, we established another clinic, in St Mary's Hospital, to assess adults with a family history of kidney disease.

I was a Trustee and Honorary Secretary of The Renal Association (2000-2004). I was the Research Secretary of the British Association for Paediatric Nephrology (2000-2002). I served on the National Kidney Research Fund grants committee (1997-2002). I became a Trustee of Kidney Research UK in 2012, with a special remit in the Alumni programme and in 2014 I was appointed to chair the charity's Research Strategy Committee.

Qualifications

Education

  • 1968-1974 St Paul's School, London
  • 1975-1978 Corpus Christi College, Cambridge
  • 1978-1981 Westminster Medical School, London

Qualifications

  • 1981 MB BS, University of London
  • 1982 MA, University of Cambridge
  • 1984 MRCP II UK
  • 1989 MD Thesis, University of London

Collaborators and affiliated staff

University of Manchester and CMFT - Main Collaborators

  • William G. Newman (Professor of Translational Genomic Medicine, Institute of Human Development)
  • Bronwyn Kerr (Professor of Genetics, St Mary's Hospital)
  • Helen Stuart (Academic Clinical Lecturer), Institute of Human Development)
  • Edward A McKenzie (Senior Experimental Officer, Faculty of Life Sciences)
  • Emma N. Hilton (Postdoctoral Research Fellow, Institute of Human Development)
  • Angela Summers (Nephrology Research Fellow, MRI)
  • Rachel Lennon (Wellcome Trust Intermediate Clinical Fellow, Institute of Human Development)
  • Nick Ashton (Senior Lecturer in Physiology, Faculty of Life Sciences)
  • Natalie J. Gardiner (Lecturer in Neurobiology, Faculty of Life Sciences)
  • Raimondo M. Cervellione (Paediatric Urologist, Royal Manchester Children's Hospital.
  • Antonino Morabito (Paediatric Surgeon, Royal Manchester Children's Hospital)
  • Susan Kimber (Professor of Stem Cells and Development, FLS)

External Institutes - Main Collaborators

University of Liverpool, UK: Patricia Murray, Bettina Wilm and Kevin Park

Newcastle University, UK: Judith A Goodship, Timothy HJ Goodship, Heather J Cordell and Heather J Lambert

UK Vesicoureteric Reflux Study Group and DNA Bank

UCL Institute of Child Health, London, UK: David A Long, Paul JD Winyard, Jennifer Huang and Jenny Papakrivopoulou

CNRS, Marseille, France: Laurent Fasano

University of Essen, Germany: Steffi Weber

University of Umea, Sweden: Hakan Hedman

Publications

2016

  • Woolf, A. S., Coletta, R., Roberts, N. A., Oltrabella, F., Khalil, B. A., & Morabito, A. (2016). Bridging the gap: functional healing of embryonic small intestine ex vivo.Journal of Tissue Engineering and Regenerative Medicine, 10, 178-182.. Publication link: bf7d75a1-8ac9-4aab-91e8-477674ed79ef
  • Woolf, A. S., Huang, J. L., Kolatsi-Joannou, M., Baluk, P., Sandford, R. N., Peters, D. J. M., ... Long, D. A. (2016). Vascular endothelial growth factor C therapy for polycystic kidney diseases.American Society of Nephrology. Journal, 27, 69-77.. Publication link: 534c150b-8810-458c-a991-d89977c407f6

2015

  • Woolf, A. (2015). Urinary tract effects of HPSE2 mutations.American Society of Nephrology. Journal, 26, 797-804. doi: 10.1681/ASN.2013090961. Publication link: f408061e-726c-439a-aed7-3aed7e1a6f13 | DOI:doi: 10.1681/ASN.2013090961
  • Woolf, A. S., Ellingford, J. M., Sergouniotis, P. I., Lennon, R., Bhaskar, S., Williams, S. G., ... Black, G. C. (2015). Pinpointing clinical diagnosis through whole exome sequencing to direct patient care.The Lancet, 385, 1916-1917.. Publication link: 6ab69180-a6d9-4527-a837-65c9a87509f5
  • Woolf, A. S., Lennon, R. S. H. M., Bierzynska, A., Randles, M. J., Kerr, B., Hillman, K. A., ... Webb, N. J. (2015). Coinheritance of COL4A5 and MYO1E mutations accentuate severity of kidney disease.Pediatric Nephrology, 30, 1459-1465.. Publication link: 2e4ec8bc-1b7b-4bf9-8529-a2953e70e3dc
  • Woolf, A. S., Randles, M. J., Huang, J. L., Byron, A., Humphries, J. D., Price, K. L., ... Lennon, R. (2015). Genetic background is a key determinant of glomerular extracellular matrix composition and organization.American Society of Nephrology. Journal, 26, 3021-3034.. Publication link: f3e1a272-4504-4277-8f9c-01c4c36eb9c7
  • Woolf, A. S., Roberts, N. A., & Hilton, E. N. (2015). From gene discovery to new biological mechanisms: heparanases and congenital urinary bladder disease.Nephrology, Dialysis, Transplantation.. Publication link: 2783cbcb-796a-4de9-99ea-e36db73a8df2
  • Woolf, A. S., Scarfe, L., Rak-Raszewska, A., Geraci, S., Darssan, D., Sharkey, J., ... Wilm, B. (2015). Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.Scientific Reports, 5, 13601.. Publication link: e188be6b-869f-4844-b435-6e237c532b70
  • Woolf, A. S., Vivante, A., Kleppa, M. J., Schulz, J., Kohl, S., Sharma, A., ... Hildebrandt, F. (2015). Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development.American Journal of Human Genetics, 97, 291-301.. Publication link: f3e60f90-a92d-4c4f-b9a4-bbe3ae9caa6f

2014

  • Alam-Faruque, Y., Hill, D. P., Dimmer, E. C., Harris, M. A., Foulger, R. E., Tweedie, S., ... Huntley, R. P. (2014). Representing kidney development using the gene ontology. PLoS ONE, 9(6), [e99864]. 10.1371/journal.pone.0099864. Publication link: 1cce0eab-cb40-4d68-9d8f-1d216e42d445 | DOI:10.1371/journal.pone.0099864
  • Murray, P. A., & Woolf, A. S. (2014). Using stem and progenitor cells to recapitulate kidney development and restore renal function. Current Opinion in Organ Transplantation, 19(2), 140-144. 10.1097/MOT.0000000000000052. Publication link: c0f6c94d-ac65-41dc-a3d6-8c9791035348 | DOI:10.1097/MOT.0000000000000052
  • Roberts, N. A., Woolf, A. S., Stuart, H. M., Thuret, R., McKenzie, E. A., Newman, W. G., & Hilton, E. N. (2014). Heparanase 2, Mutated in urofacial syndrome, Mediates peripheral neural development in Xenopus. Human Molecular Genetics, 23(16), 4302-4314. [ddu147]. 10.1093/hmg/ddu147. Publication link: b6caf3d0-fa54-4e36-b872-9e048fc8869f | DOI:10.1093/hmg/ddu147 | PubMed:24691552
  • Woolf, A. S., Dessapt-Baradez, C., White, K. E., Pan, J., Huang, J. L., Hayward, A. A., ... Gnudi, L. (2014). Targeted glomerular angiopoietin-1 therapy for early diabetic nephropathy. Journal of the Amercian Society of Nephrology, 25, 33-42.. Publication link: 4055eb1f-4480-4426-8f33-707e69f19261
  • Woolf, A. S., Stuart, H. M., & Newman, W. G. (2014). Genetics of human congenital urinary bladder disease. Pediatr Nephrol, 29(3), 353-60. 10.1007/s00467-013-2472-1. Publication link: 41dba4e3-75d7-479f-887d-90328ce50e7c | DOI:10.1007/s00467-013-2472-1 | PubMed:23584850
  • Woolf, A. S., Stuart, H. M., Roberts, N. A., McKenzie, E. A., Hilton, E. N., & Newman, W. G. (2014). Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation. Pediatr Nephrol, 29(4), 513-8. 10.1007/s00467-013-2552-2. Publication link: 9df6c2d4-23ec-4091-8ebf-13b47f8298ca | DOI:10.1007/s00467-013-2552-2 | PubMed:23832138
  • Woolf, A. S., Jenkins, D., Jennette, J. C. (Ed.), Olson, J. L. (Ed.), Silva, F. G. (Ed.), & D'Agati, V. D. (Ed.) (2014). Development of the kidney.In Heptinstall's Pathology of the Kidney. (7th ed., pp. 67-89). Philadelphia: Wolters Kluwer.. Publication link: 1efdc7ba-baed-4548-82aa-3a042fccaeec

2013

  • Anders, C., Ashton, N., Ranjzad, P., Dilworth, M. R., & Woolf, A. S. (2013). Ex Vivo Modeling of Chemical Synergy in Prenatal Kidney Cystogenesis. PLoS ONE, 8(3), [e57797]. 10.1371/journal.pone.0057797. Publication link: c2557908-4b85-41c4-b7f0-4df7f754754d | DOI:10.1371/journal.pone.0057797 | PubMed:23554868
  • Long, D. A., Kolatsi-Joannou, M., Price, K. L., Dessapt-Baradez, C., Huang, J. L., Papakrivopoulou, E., ... Woolf, A. S. (2013). Albuminuria is associated with too few glomeruli and too much testosterone. Kidney International, 83(6), 1118-1129. 10.1038/ki.2013.45. Publication link: 448dad54-5003-4f73-b62f-a5866314b6b9 | DOI:10.1038/ki.2013.45
  • Shroff, R. C., Price, K. L., Kolatsi-Joannou, M., Todd, A. F., Wells, D., Deanfield, J., ... Long, D. A. (2013). Circulating Angiopoietin-2 Is a Marker for Early Cardiovascular Disease in Children on Chronic Dialysis. PLoS ONE, 8(2), [e56273]. 10.1371/journal.pone.0056273. Publication link: 576bd3f4-259c-4ec2-b533-007a6497afe9 | DOI:10.1371/journal.pone.0056273
  • Stuart, H. M., Roberts, N. A., Burgu, B., Daly, S. B., Urquhart, J. E., Bhaskar, S., ... Yalçınkaya, F. (2013). LRIG2 mutations cause urofacial syndrome. American Journal of Human Genetics, 92(2), 259-264. 10.1016/j.ajhg.2012.12.002. Publication link: 1eeed1cd-c861-4218-ab86-7ce591e051e4 | DOI:10.1016/j.ajhg.2012.12.002 | PubMed:23313374
  • Tai, G., Ranjzad, P., Marriage, F., Rehman, S., Denley, H., Dixon, J., ... Woolf, A. S. (2013). Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas. PLoS ONE, 8(11), [e81167]. 10.1371/journal.pone.0081167. Publication link: 76c3402b-f664-465d-8c80-498a1f9092c2 | DOI:10.1371/journal.pone.0081167 | PubMed:24260555
  • Woolf, A. S., & Davies, J. A. (2013). Cell biology of ureter development. Journal of the American Society of Nephrology, 24(1), 19-25. 10.1681/ASN.2012020127. Publication link: c5a69eab-a13f-45fa-8533-ba659e25e728 | DOI:10.1681/ASN.2012020127
  • Woolf, A. S., Huang, J. L., & Long, D. A. (2013). Angiogenesis and autosomal dominant polycystic kidney disease.Pediatric Nephrology, 28, 1749-1755.. Publication link: 23f92eb0-b5c6-4f6e-af45-e75c38b4626e
  • Woolf, A. S., Newman, W. G., & Stewart, H. M. (2013). Urofacial syndrome.GeneReviews.. Publication link: 9ead78d8-9ccd-473d-8289-25a9b2e36f1d
  • Woolf, A. S., Hillman, K. A., Feehally, J. (Ed.), McIntyre, C. W. (Ed.), & Cameron, J. S. (Ed.) (2013). Chapter 4. Inherited renal disease.In Landmark Papers in Nephrology: One hundred years of renal science.. Oxford UK: Oxford University Press.. Publication link: cdbc53c6-91e9-4b71-968c-78dc6f34117c

2012

  • Lee, L. M. Y., Leung, C. Y., Tang, W. W. C., Choi, H. L., Leung, Y. C., McCaffery, P. J., ... Shum, A. S. W. (2012). A paradoxical teratogenic mechanism for retinoic acid. Proceedings of the National Academy of Sciences of the United States of America, 109(34), 13668-13673. 10.1073/pnas.1200872109. Publication link: 37b980a0-6c8e-45c6-95cd-d6aed07ac4ac | DOI:10.1073/pnas.1200872109
  • Pitera, J. E., Woolf, A. S., Albert Basson, M., & Scambler, P. J. (2012). Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. Journal of the American Society of Nephrology, 23(11), 1790-1796. 10.1681/ASN.2012020146. Publication link: 61d242a2-9f8c-4561-819a-8d6a552b4feb | DOI:10.1681/ASN.2012020146
  • Rak-Raszewska, A., Wilm, B., Edgar, D., Kenny, S., Woolf, A. S., & Murray, P. (2012). Development of embryonic stem cells in recombinant kidneys. Organogenesis, 8(4), 125-136. 10.4161/org.22597. Publication link: 91891605-7268-407e-afb0-a8e7933339ac | DOI:10.4161/org.22597
  • Woolf, A. S., Pitera, J. E., Turmaine, M., & Scambler, P. J. (2012). Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele.Genesis, 50, 892-896.. Publication link: 41d9beee-9ef5-4b92-a174-895fe8ac1b0e
  • Woolf, A., Kerecuk, L., Long, D. A., Ali, Z., Anders, C., Kolatsi-Joannou, M., ... Woolf, A. S. (2012). Expression of Fraser syndrome genes in normal and polycystic murine kidneys. Pediatric Nephrology, 27(6), 991-998. 10.1007/s00467-012-2100-5. Publication link: be6256a0-158d-44bc-a36a-027d3e648926 | DOI:10.1007/s00467-012-2100-5

2011

  • Lambert, H. J., Stewart, A., Gullett, A. M., Cordell, H. J., Malcolm, S., Feather, S. A., ... Woolf, A. S. (2011). Primary, nonsyndromic vesicoureteric reflux and nephropathy in sibling pairs: A United Kingdom cohort for a DNA bank. Clinical Journal of the American Society of Nephrology, 6(4), 760-766. 10.2215/CJN.04580510. Publication link: 83f1744d-213e-4b74-bc0c-6ec88c0ca932 | DOI:10.2215/CJN.04580510
  • Lopes, C. A. M., Prosser, S. L., Romio, L., Hirst, R. A., O'Callaghan, C., Woolf, A. S., & Fry, A. M. (2011). Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1. Journal of Cell Science, 124(4), 600-612. 10.1242/jcs.077156. Publication link: 75d3c4f1-0f58-4b65-a7c3-a75d5232cde2 | DOI:10.1242/jcs.077156
  • Weber, S., Thiele, H., Mir, S., Toliat, M. R., Sozeri, B., Reutter, H., ... Woolf, A. S. (2011). Muscarinic acetylcholine receptor m3 mutation causes urinary bladder disease and a prune-belly-like syndrome. American Journal of Human Genetics, 89(5), 668-674. 10.1016/j.ajhg.2011.10.007. Publication link: 0bf7f33c-0436-46bf-8a4d-ef8433120bc6 | DOI:10.1016/j.ajhg.2011.10.007 | PubMed:22077972
  • Woolf, A. S. (2011). Environmental influences on renal tract development: A focus on maternal diet and the glucocorticoid hypothesis. Klinische Padiatrie, 223(1), S10-S17. 10.1055/s-0030-1255876. Publication link: 545a2a37-4d17-4f67-8b75-de66d681d9c4 | DOI:10.1055/s-0030-1255876
  • Woolf, A., Marks, S. D., Gullett, A. M., Brennan, E., Tullus, K., Jaureguiberry, G., ... Woolf, A. S. (2011). Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. Pediatric Nephrology, 26(10), 1857-1861. 10.1007/s00467-011-1891-0. Publication link: 504af182-9d97-49d7-8e55-1f768308a293 | DOI:10.1007/s00467-011-1891-0

2010

  • Adalat, S., Bockenhauer, D., Ledermann, S. E., Hennekam, R. C., & Woolf, A. S. (2010). Renal malformations associated with mutations of developmental genes: Messages from the clinic. Pediatric Nephrology, 25(11), 2247-2255. 10.1007/s00467-010-1578-y. Publication link: 07125b88-f4a6-482b-b3be-99e48d5278df | DOI:10.1007/s00467-010-1578-y
  • Chan, S. K., Riley, P. R., Price, K. L., McElduff, F., Winyard, P. J., Welham, S. J. M., ... Long, D. A. (2010). Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog. American Journal of Physiology - Renal Physiology, 298(2), F346-F356. 10.1152/ajprenal.00574.2009. Publication link: b82a2c18-3a27-4532-b114-dcb9db0483af | DOI:10.1152/ajprenal.00574.2009
  • Cordell, H. J., Darlay, R., Charoen, P., Stewart, A., Gullett, A. M., Lambert, H. J., ... Goodship, J. A. (2010). Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. Journal of the American Society of Nephrology, 21(1), 113-123. 10.1681/ASN.2009060624. Publication link: ec69a60b-924a-4653-aa41-dfb676057463 | DOI:10.1681/ASN.2009060624
  • Farrugia, M. K., & Woolf, A. S. (2010). Congenital urinary bladder outlet obstruction. Fetal and Maternal Medicine Review, 21(1), 55-73. 10.1017/S0965539509990192. Publication link: 4176af37-cc48-4394-a1bf-add73608d8be | DOI:10.1017/S0965539509990192
  • Jenkins, D., Caubit, X., Dimovski, A., Matevska, N., Lye, C. M., Cabuk, F., ... Woolf, A. S. (2010). Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. Nephrology Dialysis Transplantation, 25(1), 54-60. 10.1093/ndt/gfp453. Publication link: f605a55b-4a69-4d24-8609-92431bc7786e | DOI:10.1093/ndt/gfp453
  • Lye, C. M., Fasano, L., & Woolf, A. S. (2010). Ureter myogenesis: Putting teashirt into context. Journal of the American Society of Nephrology, 21(1), 24-30. 10.1681/ASN.2008111206. Publication link: 3ec8429e-3063-4d3a-a63c-b0969a5760ef | DOI:10.1681/ASN.2008111206
  • Woolf, A. S. (2010). Angiopoietins: Vascular growth factors looking for roles in glomeruli. Current opinion in nephrology and hypertension, 19(1), 20-25. 10.1097/MNH.0b013e328333025e. Publication link: 994a5ac7-e1e4-4f1f-bb29-f468a05f0b30 | DOI:10.1097/MNH.0b013e328333025e
  • Woolf, A. S., Daly, S. B., Urquhart, J. E., Hilton, E., McKenzie, E. A., Kammerer, R. A., ... Newman, W. G. (2010). Mutations in HPSE2 cause urofacial syndrome.Am J Hum Genet, 11, 963-969.. Publication link: 6e01c2f8-a7d9-4ec7-ad1c-fbac82b93c69
  • Woolf, A., Mekahli, D., Woolf, A. S., & Bockenhauer, D. (2010). Similar renal outcomes in children with ADPKD diagnosed by screening or presenting with symptoms. Pediatric Nephrology, 25(11), 2275-2282. 10.1007/s00467-010-1617-8. Publication link: d4039447-e653-42d2-9f38-308ef515c4e3 | DOI:10.1007/s00467-010-1617-8
  • Yates, L. L., Papakrivopoulou, J., Long, D. A., Goggolidou, P., Connolly, J. O., Woolf, A. S., & Dean, C. H. (2010). The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Human Molecular Genetics, 19(23), 4663-4676. 10.1093/hmg/ddq397. Publication link: 0b2f92f5-05e4-4e2d-8965-f9267964d568 | DOI:10.1093/hmg/ddq397
  • Woolf, A. S. (2010). Genes, Urinary Tract Development, and Human Disease. In Pediatric Urology|Pediatr. Urol.. (2 ed., pp. 172-179). Philadelphia: Elsevier Inc.. 10.1016/B978-1-4160-3204-5.00012-8. Publication link: 544b8d0e-a4eb-4887-a0f4-a72cb579e678 | DOI:10.1016/B978-1-4160-3204-5.00012-8

2009

  • Adalat, S., Woolf, A. S., Johnstone, K. A., Wirsing, A., Harries, L. W., Long, D. A., ... Bockenhauer, D. (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. Journal of the American Society of Nephrology, 20(5), 1123-1131. 10.1681/ASN.2008060633. Publication link: 7b672b90-030f-4913-8580-5cd9efb14005 | DOI:10.1681/ASN.2008060633
  • Ferrante, M. I., Romio, L., Castro, S., Collins, J. E., Goulding, D. A., Stemple, D. L., ... Wilson, S. W. (2009). Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Human Molecular Genetics, 18(2), 289-303. 10.1093/hmg/ddn356. Publication link: e34d0c8a-16ad-42d3-bfb6-def062df637e | DOI:10.1093/hmg/ddn356
  • Pastorelli, L. M., Wells, S., Fray, M., Smith, A., Hough, T., Harfe, B. D., ... Greenfield, A. (2009). Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mammalian Genome, 20(3), 140-151. 10.1007/s00335-008-9169-y. Publication link: a92705c4-ada7-4dc8-a1dc-76f74eb13814 | DOI:10.1007/s00335-008-9169-y
  • Price, K. L., Woolf, A. S., & Long, D. A. (2009). Unraveling the Genetic Landscape of Bladder Development in Mice. Journal of Urology, 181(5), 2366-2374. 10.1016/j.juro.2009.01.001. Publication link: 7712d5c2-4728-4cb6-9806-e48555cff986 | DOI:10.1016/j.juro.2009.01.001
  • Woolf, A., Woolf, A. S., Gnudi, L., & Long, D. A. (2009). Roles of angiopoietins in kidney development and disease. Journal of the American Society of Nephrology, 20(2), 239-244. 10.1681/ASN.2008020243. Publication link: b131f26f-98a3-4f9e-aa12-2dc53402bae7 | DOI:10.1681/ASN.2008020243
  • Woolf, A. S., Pitera, J. E., Avner, E. D. (Ed.), Harmon, W. E. (Ed.), & Niaudet, P. (Ed.) (2009). Embryology. In Pediatric Nephrology. (6 ed., pp. 3-30). Springer.. Publication link: 90d8b1e4-510b-4be5-9281-3d1039e43917

2008

  • Caubit, X., Lye, C. M., Martin, E., Coré, N., Long, D. A., Vola, C., ... Fasano, L. (2008). Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development, 135(19), 3301-3310. 10.1242/dev.022442. Publication link: bd575a3a-ef07-4557-81ae-d35a9da54a8d | DOI:10.1242/dev.022442
  • Long, D. A., Price, K. L., Ioffe, E., Gannon, C. M., Gnudi, L., White, K. E., ... Woolf, A. S. (2008). Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney International, 74(3), 300-309. 10.1038/ki.2008.179. Publication link: f2c501ed-e313-4a89-8602-e15b3ff14711 | DOI:10.1038/ki.2008.179
  • Pitera, J. E., Scambler, P. J., & Woolf, A. S. (2008). Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Human Molecular Genetics, 17(24), 3953-3964. 10.1093/hmg/ddn297. Publication link: a6758407-e6a0-46e8-b882-2d414e77baf3 | DOI:10.1093/hmg/ddn297
  • Woolf, A. S. (2008). Perspectives on human perinatal renal tract disease. Seminars in Fetal and Neonatal Medicine, 13(3), 196-201. 10.1016/j.siny.2007.10.001. Publication link: c3ddb107-db4c-42c2-a62d-2d95feba25ef | DOI:10.1016/j.siny.2007.10.001
  • Woolf, A., Kerecuk, L., Schreuder, M. F., & Woolf, A. S. (2008). Renal tract malformations: Perspectives for nephrologists. Nature Clinical Practice Nephrology, 4(6), 312-325. 10.1038/ncpneph0807. Publication link: 13070e89-5727-441e-8a80-fc500755ad93 | DOI:10.1038/ncpneph0807

2007

  • Burgu, B., Medina Ortiz, W. E., Pitera, J. E., Woolf, A. S., & Wilcox, D. T. (2007). Vascular Endothelial Growth Factor Mediates Hypoxic Stimulated Embryonic Bladder Growth in Organ Culture. Journal of Urology, 177(4), 1552-1557. 10.1016/j.juro.2006.12.011. Publication link: 8f3caf07-8e88-4707-87fd-cc68b3ae6e2b | DOI:10.1016/j.juro.2006.12.011
  • Davis, B., Cas, A. D., Long, D. A., White, K. E., Hayward, A., Ku, C. H., ... Gnudi, L. (2007). Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia. Journal of the American Society of Nephrology, 18(8), 2320-2329. 10.1681/ASN.2006101093. Publication link: 45f8e5f0-2344-4e1a-95f4-1593affb99b0 | DOI:10.1681/ASN.2006101093
  • Farrugia, M. K., Woolf, A. S., Fry, C. H., Peebles, D. M., Cuckow, P. M., & Godley, M. L. (2007). Radiotelemetered urodynamics of obstructed ovine fetal bladders: Correlations with ex vivo cystometry and renal histopathology. BJU International, 99(6), 1517-1522. 10.1111/j.1464-410X.2007.06799.x. Publication link: c63ca8de-3725-40ce-babf-fd9a0fc30c14 | DOI:10.1111/j.1464-410X.2007.06799.x
  • Hai, T. Y., Venkatesha, S., Chan, B., Deutsch, U., Mammoto, T., Sukhatme, V. P., ... Karumanchi, S. A. (2007). Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB Journal, 21(12), 3171-3183. 10.1096/fj.07-8487com. Publication link: 7b1ead53-2242-423a-82cc-396cba4024e4 | DOI:10.1096/fj.07-8487com
  • Jenkins, D., Bitner-Glindzicz, M., Thomasson, L., Malcolm, S., Warne, S. A., Feather, S. A., ... Woolf, A. S. (2007). Mutational analyses of UPIIIA, SHH, EFNB2, and HNF1β in persistent cloaca and associated kidney malformations. Journal of Pediatric Urology, 3(1), 2-9. 10.1016/j.jpurol.2006.03.002. Publication link: 47e1abcd-2ef9-4d06-a557-0890b7b9547b | DOI:10.1016/j.jpurol.2006.03.002
  • Jenkins, D., Winyard, P. J. D., & Woolf, A. S. (2007). Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. Journal of Anatomy, 211(5), 620-629. 10.1111/j.1469-7580.2007.00808.x. Publication link: 13316410-162a-4b48-9d16-5dbbf1a93606 | DOI:10.1111/j.1469-7580.2007.00808.x
  • Kerecuk, L., Sajoo, A., McGregor, L., Berg, J., Haq, M. R., Sebire, N. J., ... Woolf, A. S. (2007). Autosomal dominant inheritance of non-syndromic renal hypoplasia and dysplasia: Dramatic variation in clinical severity in a single kindred. Nephrology Dialysis Transplantation, 22(1), 259-263. 10.1093/ndt/gfl531. Publication link: 4400354a-7708-4e40-9948-cc38b4a905fc | DOI:10.1093/ndt/gfl531
  • Price, K. L., Long, D. A., Jina, N., Liapis, H., Hubank, M., Woolf, A. S., & Winyard, P. J. D. (2007). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiological Genomics, 28(2), 193-202. 10.1152/physiolgenomics.00147.2006. Publication link: 497136dd-d7d0-43f5-80ac-999834f2663c | DOI:10.1152/physiolgenomics.00147.2006
  • Woolf, A. S., Lu, W., van, E. A. M., Fan, X., Quintero-Rivera, F., Kulkarni, S., ... Maas, R. L. (2007). Disruption of ROBO2 is associated with congenital anomalies of kidney and urinary tract and confers risk of vesicoureteric reflux.Am J Hum Genet, 60, 616-632.. Publication link: 36d0ae88-42a6-44d9-9e71-b8887de2478e
  • Woolf, A., Jenkins, D., & Woolf, A. S. (2007). Uroplakins: New molecular players in the biology of urinary tract malformations. Kidney International, 71(3), 195-200. 10.1038/sj.ki.5002053. Publication link: 724887ae-cacc-46b4-8a65-d8f706d621e2 | DOI:10.1038/sj.ki.5002053
  • Woolf, A., Woolf, A. S., & Hillman, K. A. (2007). Unilateral renal agenesis and the congenital solitary functioning kidney: Developmental, genetic and clinical perspectives. BJU International, 99(1), 17-21. 10.1111/j.1464-410X.2006.06504.x. Publication link: 3a04ad7a-8bec-400d-ae97-97a63bf1ff0c | DOI:10.1111/j.1464-410X.2006.06504.x
  • Wu, C., Thiruchelvam, N., Sui, G., Woolf, A. S., Cuckow, P., & Fry, C. H. (2007). Ca2+ Regulation in Detrusor Smooth Muscle From Ovine Fetal Bladder After In Utero Bladder Outflow Obstruction. Journal of Urology, 177(2), 776-780. 10.1016/j.juro.2006.09.070. Publication link: eea627d9-1f11-4d3a-b80b-fe3cec1be79a | DOI:10.1016/j.juro.2006.09.070

2006

  • Burgu, B., McCarthy, L. S., Shah, V., Long, D. A., Wilcox, D. T., & Woolf, A. S. (2006). Vascular endothelial growth factor stimulates embryonic urinary bladder development in organ culture. BJU International, 98(1), 217-225. 10.1111/j.1464-410X.2006.06215.x. Publication link: 0380d9ce-dc1c-4739-b089-fb81093fbd6b | DOI:10.1111/j.1464-410X.2006.06215.x
  • Chiu, M. G., Johnson, T. M., Woolf, A. S., Dahm-Vicker, E. M., Long, D. A., Guay-Woodford, L., ... Winyard, P. J. D. (2006). Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. American Journal of Pathology, 169(6), 1925-1938. 10.2353/ajpath.2006.060245. Publication link: 69c4fe4c-e0f1-41ba-a351-2051fabe82c3 | DOI:10.2353/ajpath.2006.060245
  • Jenkins, D., Bitner-Glindzicz, M., Malcolm, S., Allison, J., de Bruyn, R., Flanagan, S., ... Woolf, A. S. (2006). Mutation analyses of Uroplakin II in children with renal tract malformations. Nephrology Dialysis Transplantation, 21(12), 3415-3421. 10.1093/ndt/gfl465. Publication link: 24eb473b-cb1b-476d-80a2-36b10609cee5 | DOI:10.1093/ndt/gfl465
  • Long, D. A., Mu, W., Price, K. L., Roncal, C., Schreiner, G. F., Woolf, A. S., & Johnson, R. J. (2006). Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension. American Journal of Physiology - Renal Physiology, 291(6), F1248-F1254. 10.1152/ajprenal.00096.2006. Publication link: 389b3333-05e6-4427-94ab-2d3517d465fe | DOI:10.1152/ajprenal.00096.2006
  • Woolf, A., & Woolf, A. S. (2006). Unilateral multicystic dysplastic kidney. Kidney International, 69(1), 190-193. 10.1038/sj.ki.5000015. Publication link: f712146e-c343-48e0-98dc-981bfad68cfd | DOI:10.1038/sj.ki.5000015
  • Woolf, A. S., Jenkins, D., Jennette, J. C. (Ed.), Olson, J. L. (Ed.), Schwartz, M. M. (Ed.), & Silva, F. G. (Ed.) (2006). Development of the kidney. In Heptinstall's Pathology of the Kidney. (6 ed., pp. 71-95). Philadelphia-New York: Lippincott-Raven.. Publication link: bce4e3f6-1edf-4e60-b81c-4b83246c33ea
  • Woolf, A. S., Stringer, M. D. (Ed.), Mouriquand, P. D. E. (Ed.), & Oldham, K. T. (Ed.) (2006). The single kidney. In Pediatric Surgery and Urology: Long-Term Outcomes. (pp. 675-682). Cambridge: Cambridge University Press.. Publication link: 5231ccfe-3ceb-4a27-a6aa-dd90d8f5778a
  • Woolf, A., & Woolf, A. S. (2006). Renal hypoplasia and dysplasia: Starting to put the puzzle together. Journal of the American Society of Nephrology, 17(10), 2647-2649. 10.1681/ASN.2006080841. Publication link: 99eeee3b-5a9a-4f76-98ba-19f473cb963d | DOI:10.1681/ASN.2006080841

2005

  • Jadeja, S., Smyth, I., Pitera, J. E., Taylor, M. S., Van Haelst, M., Bentley, E., ... Scambler, P. J. (2005). Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nature Genetics, 37(5), 520-525. 10.1038/ng1549. Publication link: 480dd74e-1eef-4af7-90ca-89748ac3d8e5 | DOI:10.1038/ng1549
  • Jenkins, D., Bitner-Glindzicz, M., Malcolm, S., Hu, C. C. A., Allison, J., Winyard, P. J. D., ... Woolf, A. S. (2005). De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. Journal of the American Society of Nephrology, 16(7), 2141-2149. 10.1681/ASN.2004090776. Publication link: 670548a8-f43f-4493-93c0-4b7fbef41f5f | DOI:10.1681/ASN.2004090776
  • Tse, H. K. W., Leung, M. B. W., Woolf, A. S., Menke, A. L., Hastie, N. D., Gosling, J. A., ... Shum, A. S. W. (2005). Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome. American Journal of Pathology, 166(5), 1295-1307. 10.1016/S0002-9440(10)62349-8. Publication link: 5e07dde2-7382-4b8b-af95-128b56acbc18 | DOI:10.1016/S0002-9440(10)62349-8
  • Welham, S. J. M., Riley, P. R., Wade, A., Hubank, M., & Woolf, A. S. (2005). Maternal diet programs embryonic kidney gene expression. Physiological Genomics, 22, 48-56. 10.1152/physiolgenomics.00167.2004. Publication link: f1028940-38d8-46e0-9557-cec0ed1b5c1a | DOI:10.1152/physiolgenomics.00167.2004