Professor Adrian Woolf MA MD

Photograph of Adrian Woolf

Chair in Paediatric Science

Room D2515
Michael Smith Building
University of Manchester
Oxford Road
M13 9PT



University of Manchester

Chair of Paediatric Science, Faculty of Medical and Human Sciences (from 2010)

Centre Lead for Paediatrics and Child Health, Institute of Human Development (from 2014)

Member of Cross Faculty Renal Biology Group

Royal Manchester Children's Hospital

Honorary Consultant in Paediatric Nephrology (from 2010; revalidated 2015)

Member of Greater Manchester Academic Nephrology Network

President Elect, Manchester Paediatric Club section of Manchester Medical Society (from 2015)

Manchester Medical School

Lead for Phase II Nutrition, Metabolism and Excretion Module, Manchester Medical School (2011-2014)

Outside Manchester

Honorary Professor University College London (from 2010)

Kidney Research UK Trustee (from 2012), Alumni Ambassador (from 2013) and Chair of Research Strategy Committee (from 2014),

Member of UK National Renal Research Strategy Steering Group (from 2014)

Member of European Society for Paediatric Nephrology Working Group on Congenital Urinary Tract and Kidney Malformations (from 2014)

Memberships of Committees and Professional Bodies

  • Academic Paediatrics Association GBI
  • American Society of Nephrology
  • Association of Physicians of Great Britain and Ireland
  • British Association for Paediatric Nephrology
  • European Society for Pediatric Nephrology
  • Manchester Medical Society
  • Manchester Paediatric Club
  • Royal College of Paediatrics and Child Health
  • The Renal Association


Current projects

"UK Regenerative Medicine Platform Safety Hub" With S Williams, S Kimber, R Lennon and MC Asselin. Funded by MRC/BBSRC/EPSRC.

"Exploring whether small bowel can be lengthened in an ex vivo model" With A Morabito and R Coletta. Funded by the CMFT Short Bowel Reseach Fund.

"Using zebrafish to implicate novel genes in the early stages of diabetic kidney disease" With DA Long (UCL), S Wilson (UCL) and M Kolatsi-Joannou (UCL). Funded by Diabetes UK.

"Molecular bases of congenital bladder diseases". With NJ Gardiner, WG Newman, NA Roberts and EN HIlton. Funded by MRC.

"RENAL TRACT: novel neurological perspectives on congenital bladder disease". With NJ Gardiner. Funded by Horizon 2020 Marie Sklodowska-Curie Initial Training Network.

"Modelling therapies for surgical adhesions". With SE Herrick , S Namvar and B Wilm (Liverpool). Funded by MRC.

"Towards novel therpaies for a genetic congenital neuropathy affecting the urinary bladder". With EN Hilton, WG Newman and SJ Kimber. Funded by Newlife Foundation.

"Molecular characterisation of bladder exstrophy and related disorders of the lower urinary tract" With WG Newman, G Beaman and M Cervellione. Funded by Newlife Foundation

Methodological Knowledge

Anatomy and biology of normal and abnormal renal tract development, differentiation and regeneration.

Genetic and biological studies of autonomic and other peripheral neuropathies.

Novel translational therapies using growth factors and precursor cells.

Models of human disease in mice and frogs.


University of Manchester MB ChB programme

Lead for Phase II Nutrition, Metabolism and Excretion Module (2011-2014)

Congratulations on recently awarded theses.

2015 PhD HM Stuart (co-supervisor WG Newman) Urofacial syndrome: a genetic model to understand human urinary tract abnormalities

2015 PhD A Gofrehi (second supervisor K Hentges) Microphthalmia genes in mammalian organogenesis

2015 PhD M Randles (primary supervisor R Lennon) Proteomic analyses of kidney glomerular extracelular matrix in health and disease

2015 MRes with Distinction R Taylor (co-supervisor EN Hilton) The heparanase axis and peripheral neuron regeneration

2015 MRes with Distinction R Hall (primary supervisor WG Newman) Genetic characterisation of urofacial syndrome and related conditions of the bladder

Currently supervised PhD students

R Coletta (second supervisor A Morabito)  Exploring whether small bowel can be lengthened in an ex vivo model

E Hindi (primary supervisor NJ Gardiner) Pathogenesis of diabetic urinary bladder disease

F Lopes (second supervisor NJ Gardiner) Novel neurological perspectives on congenital renal tract diseases

T Faris (primary supervisor SJ Kimber) Genetic manipulation of pluripotent stem cells to model kidney disease

Currently supervised MRes students

K Chopra (co-supervisor EN Hilton) Urofacial syndrome and regenerative medicine

S Mezher (co-supervisor P Ranjzad) Mechanisms of fibrosis in chronic kidney disease

Social Responsibility

Trustee, Alumni Lead, and Research Strategy Committee Chair, Kidney Research UK

Undertaking interactive research seminars at primary and secondary schools



In 2010 I took up a new Chair, Professor of Paediatric Science in the Faculty of Medical and Human Sciences at the University of Manchester. I am also an Honorary Consultant in Paediatric Nephrology in the Royal Manchester Children's Hospital.

Previously, in 1998, I established an academic centre for Nephrology and Urology at the UCL Institute of Child Health, London, which I headed until the end of 2009.

A main research aim is to find out why people are sometimes born with abnormal kidneys, ureters and bladders. These are the main causes of children needing long term renal dialysis and kidney transplantation. I am also working on translational therapies, including those based on growth factors and precursor cells, for kidney, bladder and, more recently, neural disease.

My research and development work unites speciality clinical services with new perspectives from Developmental, Cell Biology and Genomic sciences. I have published 138 original research publications. I have supervised clinical and science students leading to 15 PhD, three MD, one MRes, two MSc and one MPhil awarded theses. I currenlty supervise four PhD students (two as lead supervisor) and two MRes students.

In 2015, The Renal Association gave me their Lockwood Award, and I will be their 2016 de Wardener Lecturer, both in recognition of my outstanding record in research and teaching.

From 2006-2009 I undertook a clinic at Great Ormond Street Hospital, London, focusing on renal tract malformations, which had an impact on diagnosis of these conditions and genetic counseling. With clinical genetics and adult nephrology colleagues, I established a similar clinic in the Royal Manchester Children's Hospital in 2010. In 2012, we established another clinic, in St Mary's Hospital, to assess adults with a family history of kidney disease.

I was a Trustee and Honorary Secretary of The Renal Association (2000-2004). I was the Research Secretary of the British Association for Paediatric Nephrology (2000-2002). I served on the National Kidney Research Fund grants committee (1997-2002). I became a Trustee of Kidney Research UK in 2012, with a special remit in the Alumni programme and in 2014 I was appointed to chair the charity's Research Strategy Committee.



  • 1968-1974 St Paul's School, London
  • 1975-1978 Corpus Christi College, Cambridge
  • 1978-1981 Westminster Medical School, London


  • 1981 MB BS, University of London
  • 1982 MA, University of Cambridge
  • 1984 MRCP II UK
  • 1989 MD Thesis, University of London

Collaborators and affiliated staff

University of Manchester and CMFT - Main Collaborators

  • William G. Newman (Professor of Translational Genomic Medicine, Institute of Human Development)
  • Bronwyn Kerr (Professor of Genetics, St Mary's Hospital)
  • Helen Stuart (Academic Clinical Lecturer), Institute of Human Development)
  • Edward A McKenzie (Senior Experimental Officer, Faculty of Life Sciences)
  • Emma N. Hilton (Postdoctoral Research Fellow, Institute of Human Development)
  • Angela Summers (Nephrology Research Fellow, MRI)
  • Rachel Lennon (Wellcome Trust Intermediate Clinical Fellow, Institute of Human Development)
  • Nick Ashton (Senior Lecturer in Physiology, Faculty of Life Sciences)
  • Natalie J. Gardiner (Lecturer in Neurobiology, Faculty of Life Sciences)
  • Raimondo M. Cervellione (Paediatric Urologist, Royal Manchester Children's Hospital.
  • Antonino Morabito (Paediatric Surgeon, Royal Manchester Children's Hospital)
  • Susan Kimber (Professor of Stem Cells and Development, FLS)

External Institutes - Main Collaborators

University of Liverpool, UK: Patricia Murray, Bettina Wilm and Kevin Park

Newcastle University, UK: Judith A Goodship, Timothy HJ Goodship, Heather J Cordell and Heather J Lambert

UK Vesicoureteric Reflux Study Group and DNA Bank

UCL Institute of Child Health, London, UK: David A Long, Paul JD Winyard, Jennifer Huang and Jenny Papakrivopoulou

CNRS, Marseille, France: Laurent Fasano

University of Essen, Germany: Steffi Weber

University of Umea, Sweden: Hakan Hedman



  • Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJM, McDonald DM, Price KL, Winyard PJD, Long DA. (2016). Vascular endothelial growth factor C therapy for polycystic kidney diseases. J A S N, 27, 69-77. eScholarID:260766


  • Coletta R, Roberts NA, Oltrabella F, Khalil BA, Morabito A, Woolf AS. (2015). Bridging the gap: functional healing of embryonic small intestine ex vivo. J Tissue Eng Regen Med, eScholarID:269366
  • Ellingford JM, Sergouniotis PI, Lennon R, Bhaskar S, Williams SG, Hillman KA, O’Sullivan J, Hall G, Ramsden SC, Lloyd IC, Woolf AS, Black GC. (2015). Pinpointing clinical diagnosis through whole exome sequencing to direct patient care. Lancet, 385, 1916-1917. eScholarID:260481
  • Lennon R Stuart HM, Bierzynska A, Randles MJ, Kerr B, Hillman KA, Batra G, Campbell J, Storey H, Flinter FA, Koziell A, Welsh GI, Saleem MA, Webb NJ, Woolf AS. (2015). Coinheritance of COL4A5 and MYO1E mutations accentuate severity of kidney disease. Pediatr Nephrol, 30, 1459-1465. eScholarID:258882
  • Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, Lennon R. (2015). Genetic background is a key determinant of glomerular extracellular matrix composition and organization. J A S N, 26, 3021-3034. eScholarID:259068
  • Roberts NA, Hilton EN, Woolf AS. (2015). From gene discovery to new biological mechanisms: heparanases and congenital urinary bladder disease. N D T, eScholarID:269573
  • Scarfe L, Rak-Raszewska A, Geraci S, Darssan D, Sharkey J, Huang J, Burton NC, Mason D, Ranjzad P, Kenny S, Gretz N, Park K, García-Fiñana M, Woolf AS, Murray PA, Wilm B. (2015). Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Sci Rep, 5, 13601. eScholarID:269458
  • Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB,...Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS. (2015). Urinary tract effects of HPSE2 mutations. J A S N, 26, 797-804. eScholarID:230894 | DOI:doi: 10.1681/ASN.2013090961
  • Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship THJ, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F. (2015). Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development. \A J H G, 97, 291-301. eScholarID:269265


  • Woolf AS, Jenkins D. (2014). Development of the kidney. In Jennette JC, Olson JL, Silva FG, D'Agati VD (Ed.), Heptinstall's Pathology of the Kidney. (pp. 67-89). Philadelphia: Wolters Kluwer. eScholarID:236524
  • Alam-Faruque Y, Hill DP, Dimmer EC, Harris MA, Foulger RE, Tweedie S, Attrill H, Howe DG, Thomas SR, Davidson D, Woolf AS, Blake JA, Mungall CJ, O'Donovan C, Apweiler R, Huntley RP. (2014). Representing kidney development using the gene ontology. PLoS One, 9, e99864. eScholarID:230893
  • Dessapt-Baradez C, Woolf AS, White KE, Pan J, Huang JL, Hayward AA, Locatelli M, Diennet M, Price KL, Kolatsi-Joannou M, Webster Z, Smillie SJ, Nair V, Kretzler M, Cohen CD, Long DA, Gnudi L. (2014). Targeted glomerular angiopoietin-1 therapy for early diabetic nephropathy. Journal of the Amercian Society of Nephrology, 25, 33-42. eScholarID:203147
  • Murray PA, Woolf AS. (2014). Using stem and progenitor cells to recapitulate kidney development and restore renal function. Curr Opin Organ Transplant, 19, 140-144. eScholarID:215885
  • Roberts NA, Woolf AS, Stuart HM, Thuret R, McKenzie EA, Newman WG, Hilton EN. (2014). Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus. H M G, 23, 4302-4314. eScholarID:222871
  • Woolf AS, Stuart HM, Newman WG. (2014). Genetics of human congenital urinary bladder disease. Pediatric Nephrology, 29, 353-360. eScholarID:203148
  • Woolf AS, Stuart HM, Roberts NA, McKenzie EA, Hilton EN, Newman WG. (2014). Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation. Pediatric Nephrology, 29, 513-518. eScholarID:203149


  • Hillman KA, Woolf AS. (2013). Chapter 4. Inherited renal disease. In Feehally J, McIntyre CW, Cameron JS (Ed.), Landmark Papers in Nephrology: One hundred years of renal science. (pp. 86). Oxford UK: Oxford University Press. eScholarID:210930
  • Anders C, Ashton N, Ranjzad P, Dilworth MR, Woolf AS. (2013). Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis. PLoS ONE, 8, e57797. eScholarID:191094
  • Huang JL, Woolf AS, Long DA. (2013). Angiogenesis and autosomal dominant polycystic kidney disease. Pediatric Nephrology, 28, 1749-1755. eScholarID:203143
  • Long DA, Kolatsi-Joannou M, Price KL, Dessapt-Baradez C, Papakrivopoulou E, Hubank M, Korstanje R, Gnudi L, Woolf AS. (2013). Albuminuria is associated with too few glomeruli and too much testosterone. Kidney International, 83(6), 1118-1129. eScholarID:191095 | DOI:10.1038/ki.2013.45
  • Newman WG, Woolf AS, Stewart HM. (2013). Urofacial syndrome. GeneReviews, eScholarID:210378
  • Shroff RC, Price KL, Kolatsi-Joannou M, Todd AF, Wells D, Deanfield J, Johnson RJ, Rees L, Woolf AS, Long DA. (2013). Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis. PLoS ONE, 8, e56273. eScholarID:191092
  • Stuart HM, Roberts NA, Bergu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson J, Mermerkaya M, Silay MS, Lewis MA, Olondriz BO, Gener B, Beetz C, Varga RE, Gülpınar O, Süer E, Yalçınkaya F, Gücük A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG. (2013). LRIG2 mutations cause urofacial syndrome. American Journal of Human Genetics, 92, 259-264. eScholarID:191093
  • Tai G, Ranjzad P, Marriage F, Rehman S, Denley H, Dixon J, Mitchell K, Day PJ, Woolf AS. (2013). Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas. PLoS ONE, 8(e81167), eScholarID:213240
  • Woolf AS, Davies JA. (2013). Cell biology of ureter development. Journal of the American Society of Nephrology, 24, 19-25. eScholarID:191088


  • Kerecuk L, Long DA, Ali X, Anders C, Kolatsi-Joannou M, Scambler PJ, Woolf AS. (2012). Expression of Fraser syndrome genes in normal and polycystic murine kidneys. Pediatric Nephrology, 27, 991-998. eScholarID:168350 | DOI:10.1007/s00467-012-2100-5
  • Lee LM, Leung CY, Tang WW, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS, Shum AS. (2012). A paradoxical teratogenic mechanism for retinoic acid. Proceedings of the National Academy of Sciences of the United States of America, 109(34), 13668-13673. eScholarID:168354 | DOI:10.1073/pnas.1200872109
  • Pitera JE, Turmaine M, Woolf AS, Scambler PJ. (2012). Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele. Genesis, 50, 892-896. eScholarID:191090
  • Pitera JE, Woolf AS, Basson AM, Scambler PJ. (2012). Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. Journal of the American Society of Nephrology, 23, 1790-1796. eScholarID:191089
  • Pitera JE, Woolf AS, Basson MA, Scambler PJ. (In-press). Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. Journal of the Amercian Society of Nephrology, eScholarID:175870
  • Rak-Raszewska A, Wilm B, Edgar D, Kenny S, Woolf AS, Murray P. (2012). Development of embryonic stem cells in recombinant kidneys. Organogenesis, 8, 125-136. eScholarID:191091


  • Lambert HJ, Stewart A, Gullett AM, Cordell HJ, Malcolm S, Feather SA, Goodship JA, Goodship TH, Woolf AS; on behalf of the UK VUR Study Group. (2011). Primary, Nonsyndromic Vesicoureteric Reflux and Nephropathy in Sibling Pairs: A United Kingdom Cohort for a DNA Bank. Clin J Am Soc Nephrol, 6, 760-766. eScholarID:121941 | DOI:10.2215/CJN.04580510
  • Lopes CAM, Prosser SL, Romio L, Hirst RA, O'Callaghan C, Woolf AS, Fry AM. (2011). Centriolar satellites are assembly points for proteins implicated in human ciliopathies including oral-facial-digital syndrome 1. J Cell Sci, 124, 600-612. eScholarID:118346 | DOI:10.1242/jcs.077156
  • Marks SD, Gullett AM, Brennan E, Tullus K, Jaureguiberry G, Klootwijk E, Stanescu HC, Kleta R, Woolf AS. (2011). Renal FMD may not confer a familial hypertensive risk nor is it caused by ACTA2 mutations. Pediatric Nephrology, 26, 1857-1861. eScholarID:130304 | DOI:10.1007/s00467-011-1891-0
  • Weber S, Thiele H, Mir S, Toliat MR, Sozeri B, Reutter H, Draaken M, Ludwig M, Altmüller J, Frommolt P, Stuart HM, Ranjzad P, Hanley NA, Jennings R, Newman WG, Wilcox DT, Thiel U, Schlingmann K-P, Beetz R, Hoyer PF, Konrad M, Schaefer F, Nürnberg P, Woolf AS. (2011). Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune -belly-like syndrome. Am J Hum Genet, 89, 668-674. eScholarID:136152 | DOI:10.1016/j.ajhg.2011.10.007
  • Woolf AS. (2011). Environmental influences on renal tract development: a focus on maternal diet and the glucocorticoid hypothesis. Klin Padiatr, 223, S10-S17. eScholarID:121942 | DOI:10.1055/s-0030-1255876


  • Woolf AS. (2010). Genes, urinary tract development and human disease. In Gearhart JP, Rink RC, Mouriquand PDE (Ed.), Pediatric Urology. (pp. 172-179). Philadelphia: Elsevier. eScholarID:80434
  • Adalat S, Bockenhauer D, Ledermann SE, Hennekam RC, Woolf AS. (2010). Renal malformations associated with mutations of developmental genes: messages from the clinic. Pediatric Nephrology, 11, 2242-2255. eScholarID:90072
  • Chan S-K, Riley PR, Price KL, McElduff F, Winyard PJ, Welham SJ, Woolf AS, Long DA. (2010). Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog. Am J Physiol Renal Physiol, 298, F346-F356. eScholarID:77885 | DOI:10.1152/ajprenal.00574.2009
  • Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, The UK VUR Study Group, Malcolm S, Feather SA, Goodship THJ, Woolf AS, Kenda RB, Goodship JA. (2010). Whole-genome linkage and association scan in primary, non-syndromic vesicoureteric reflux. J Am Soc Nephrol, 21, 113-123. eScholarID:77888 | DOI:10.1681/ASN.2009060624
  • Daly SB, Urquhart JE, Hilton E, McKenzie EA, Kammerer RA, Lewis M, Kerr B, Stuart H, Donnai D, Long DA, Burgu B, Aydogdu O, Derbent M, Garcia-Minaur S, Reardon W, Gener B, Shalev S, Smith R, Woolf AS, Black GC, Newman WG. (2010). Mutations in HPSE2 cause urofacial syndrome. Am J Hum Genet, 11, 963-969. eScholarID:83802
  • Farrugia MK, Woolf AS. (2010). Congenital urinary bladder outlet obstruction. Fetal and Maternal Medicine Review, 21, 155-173. eScholarID:80432
  • Jenkins D, Caubit X, Dimovski A, Matevska N, Lye CM, Cabuk F, Gucev Z, Tasic V, Fasano L, Woolf AS. (2010). Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. Nephrol Dial Transplant, 25, 54-60. eScholarID:77890 | DOI:10.1093/ndt/gfp453
  • Lye CM, Fasano L, Woolf AS. (2010). Ureter myogenesis: putting Teashirt into context. J Am Soc Nephrol, 21, 24-30. eScholarID:80427 | DOI:10.1681/ASN.2008111206
  • Mekahli D, Woolf AS, Bockenhauer D. (2010). Similar renal outcomes in children with ADPKD diagnosed by screening or presenting with symptoms. Pediatric Nephrology, 11, 2275-2282. eScholarID:90073
  • Woolf AS. (2010). Angiopoietins: vascular growth factors looking for roles in glomeruli. Curr Opin Nephrol Hypertens, 19, 20-25. eScholarID:80429 | DOI:10.1097/MNH.0b013e328333025e
  • Yates LY, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH. (2010). The planar cell polarity gene Vangl2 is required for mammalian kidney branching morphogenesis and glomerular maturation. Human Molecular Genetics, 19, 4663-4676. eScholarID:93790 | DOI:10.1093/hmg/ddq397


  • Woolf AS, Pitera JE. (2009). Embryology. In Avner ED, Harmon WE, Niaudet P (Ed.), Pediatric Nephrology. (pp. 3-30). Springer. eScholarID:80433
  • Adalat S, Woolf AS, Johnstone KA, Wirsing A, Harries LW, Long DA, Hennekam RC, Ledermann SE, Rees L, vant Hoff W, Marks SD, Trompeter RS, Tullus K, Winyard PJ, Cansick J, Mushtaq I, Dhillon HK, Bingham C, Edghill EL, Shroff R, Stanescu H, Ryffel G, Ellard S, Bockenhauer D. (2009). Hepatocyte Nuclear Factor 1B mutations associate with hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol, 20, 1123-1131. eScholarID:77891 | DOI:10.1681/ASN.2008060633
  • Ferrante MI, Romio L, Castro S, Collins JE, Goulding DA, Stemple DL, Woolf AS, Wilson SW. (2009). Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet, 18, 289-303. eScholarID:77894 | DOI:10.1093/hmg/ddn356
  • Pastorelli L, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf AS, Cheeseman M, Greenfield A. (2009). Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome, 20, 140-151. eScholarID:77893 | DOI:10.1007/s00335-008-9169-y
  • Price KL, Woolf AS, Long DA. (2009). Unravelling the genetic landscape of urinary bladder development in mice. J Urol, 181, 2366-2374. eScholarID:77892 | DOI:10.1016/j.juro.2009.01.001
  • Woolf AS, Gnudi L, Long DA. (2009). Roles of angiopoietins in kidney development and disease. J Am Soc Nephrol, 20, 239-244. eScholarID:80430 | DOI:10.1681/ASN.2008020243


  • Caubit X, Lye CM, Martin E, Core N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L. (2008). Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development, 135, 3301-3310. eScholarID:77897 | DOI:10.1242/dev.022442
  • Kerecuk L, Schreuder MF, Woolf AS. (2008). Renal tract malformations: perspectives for nephrologists. Nat Clin Pract Nephrol, 4, 312-325. eScholarID:80431 | DOI:10.1038/ncpneph0807
  • Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, White KE, Yancopoulos GD, Rudge JS, Woolf AS. (2008). Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney International, 74(3), 300-309. eScholarID:77898 | DOI:10.1038/ki.2008.179
  • Pitera JE, Scambler PJ, Woolf AS. (2008). Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Human Molecular Genetics, 17(24), 3953-3964. eScholarID:77895 | DOI:10.1093/hmg/ddn297
  • Woolf AS. (2008). Perspectives on human perinatal renal tract disease. Semin Fetal Neonatal Med, 13, 196-201. eScholarID:80435 | DOI:10.1016/j.siny.2007.10.001


  • Burgu B, Medina Ortiz WE, Pitera JE, Woolf AS, Wilcox DT. (2007). Vascular endothelial growth factor mediates hypoxic-stimulated embryonic urinary bladder growth in organ culture. J Urol, 177, 1552-1557. eScholarID:78014 | DOI:10.1016/j.juro.2006.12.011
  • Davis B, Dei Cas A, Long DA, White KE, Hayward A, Ku CH, Woolf AS, Bilous R, Viberti G, Gnudi L. (2007). Podocyte-specific, induced overexpression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia. J Am Soc Nephrol, 18, 2320-2328. eScholarID:78012 | DOI:10.1681/ASN.2006101093
  • Farrugia MK, Woolf AS, Fry CH, Peebles DM, Cuckow PM, Godley ML. (2007). Radiotelemetered urodynamics of obstructed ovine fetal bladders: correlations with ex-vivo cystometry and renal histopathology. BJU Int, 99, 1517-1522. eScholarID:78013 | DOI:10.1111/j.1464-410X.2007.06799.x
  • Jenkins D, Bitner-Glindzicz M, Thomasson L, Malcolm S, Warne SA, Feather SA, Flanagan SE, Ellard S, Bingham C, Santos L, Zinn A, Henkemeyer M, Baker LA, Wilcox DT, Woolf AS. (2007). Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1B in persistent cloaca and associated kidney malformations. J Pediatr Urol, 3, 2-9. eScholarID:78016 | DOI:10.1016/j.jpurol.2006.03.002
  • Jenkins D, Winyard PJD, Woolf AS. (2007). Immunohistochemical analysis of sonic hedgehog signalling in normal human urinary tract development. J Anat, 211, 620-629. eScholarID:78009 | DOI:10.1111/j.1469-7580.2007.00808.x
  • Jenkins D, Woolf AS. (2007). Uroplakins: new molecular players in the biology of urinary tract malformations. Kidney Int, 71, 195-200. eScholarID:80439 | DOI:10.1038/
  • Kerecuk L, Sajoo A, McGregor L, Berg J, Haq MR, Sebire NJ, Bingham C, Edghill EL, Ellard S, Taylor J, Rigden S, Flinter FA, Woolf AS. (2007). Autosomal dominant inheritance of non-syndromic renal hypoplasia and dysplasia: dramatic variation in clinical severity in a single kindred. Nephrol Dial Transplant, 22, 259-263. eScholarID:78019
  • Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi J, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL. (2007). Disruption of ROBO2 is associated with congenital anomalies of kidney and urinary tract and confers risk of vesicoureteric reflux. Am J Hum Genet, 60, 616-632. eScholarID:78015
  • Price KL, Long DA, Jina N, Liapis H, Hubank M, Woolf AS, Winyard PJ. (2007). Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo. Physiol Genomics, 23, 193-202. eScholarID:78017
  • Woolf AS, Hillman KA. (2007). Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives. BJU Int, 99, 17-21. eScholarID:80442 | DOI:10.1111/j.1464-410X.2006.06504.x
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  • Woolf AS, Jenkins D. (2006). Development of the kidney. In Jennette JC, Olson JL, Schwartz MM, Silva FG (Ed.), Heptinstall's Pathology of the Kidney. (pp. 71-95). Philadelphia-New York: Lippincott-Raven. eScholarID:80440
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  • Chiu MG, Johnson TM, Woolf AS, Dahm-Vicker EM, Long DA, Guay-Woodford L, Hillman KA, Bawumia S, Venner K, Hughes RC, Poirier F, Winyard PJ. (2006). Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol, 169, 1925-1938. eScholarID:80443 | DOI:10.2353/ajpath.2006.060245
  • Jenkins D, Bitner-Glindzicz M, Malcolm S, Allison J, de Bruyn R, Flanagan S, Thomas DF, Belk RA, Feather SA, Bingham C, Southgate J, Woolf AS. (2006). Mutation analyses of Uroplakin II in children with renal tract malformations. Nephrol Dial Transplant, 21, 3415-3421. eScholarID:80445 | DOI:10.1093/ndt/gfl465
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  • Jadeja S, Smyth I, Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J, Chalepakis G, Philip N, Perez Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler PJ. (2005). Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet, 37, 520-525. eScholarID:80451 | DOI:10.1038/ng1549
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  • Welham SJ, Riley PR, Wade A, Hubank M, Woolf AS. (2005). Maternal diet programs embryonic kidney gene expression. Physiol Genomics, 22, 48-56. eScholarID:80452 | DOI:10.1152/physiolgenomics.00167.2004